Just 21 balls were bowled in the 5th and final T20I when rain came in between and forced the clash to be called off in Bengaluru.
The five-match T20I series finished tied at 2-2.
Rain returned to stop play following India lost both Ishan Kishan (15) and Ruturaj Gaikwad (10) early in the powerplay.
Bengaluru weather forecast had shown that there was a 90% chance of rain intrusion.
Before, a heavy shower earlier intervened in the start in Bengaluru after Keshav Maharaj triumphed the toss and chose to bowl, who led SA in the absence of injured Temba Bauma in the final game of the series.
Proteas made 3 changes with Tristan Stubbs, Reeza Hendricks and Kagiso Rabada replacing Bavuma, Tabraiz Shamsi and Marco Jansen.
Series shared 2-2 however India depart with a bunch of positives.