Punjab Kings made a marvelous start with Kagiso Rabada dismissing the skipper Rohit Sharma early (28), whilst Vaibhav Arora removing Ishan Kishan on 3.
The responsibility is now on youngsters Tilak Varma and Dewald Brevis to cruise the MI out of trouble.
Shikhar Dhawan scored a magnificent 70 whilst Mayank Agarwal also returned to run-scoring with a 52-run knock, as Punjab Kings put up 198/5 in 20 overs following being invited to bat first.
The opening partners forged a 97-run partnership prior the MI affect PBKS with regular wickets, as Bairstow (13) and Livingstone (2) went down cheaply in the innings.
Nevertheless, Jitesh Sharma (30*), along with Shahrukh Khan (15) supplied Punjab Kings with a late push to take the side to near-200-run mark in the match.
For the MI, Basil Thampi grabbed 2 wickets but he was fairly expensive, ceding 47 off his 4 overs.
Murugan Ashwin, Jaydev Unadkat and Jasprit Bumrah all fetched a wicket each.